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01185-7/asset/d5eb12d4-991b-47db-a46f-a63de0a6e7a5/main.assets/gr2_lrg.jpg "Amycretin, a novel, unimolecular GLP-1 and amylin receptor agonist administered subcutaneously: results from a phase 1b/2a randomised controlled study - The Lancet")
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Best in 7 days
Best in 7 days
Best in 7 days
Best in 7 days
4.7 ★★★★★
Based on 898 reviews
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Product Reviews
★★★★★ 5
Saved my skin barrier!!
I rarely write reviews, but this product truly deserves it. I have sensitive, dry skin with mild to moderate rosacea that became even more fragile after chemotherapy. While trying to repair my skin barrier, I overdid it with actives and completely wrecked my skin — it was red, raw, burning, and peeling.
I turned to ChatGPT for help, and this Avene Cicalfate+ was one of the top recommendations. I started using it about three weeks ago, and wow — the difference is incredible! My skin has healed beautifully. The redness is dramatically reduced, the irritation is gone, and my skin feels soft, smooth, and calm again.
The texture is soft and luxurious without being sticky. I love that there’s no noticeable scent, which is perfect for sensitive skin. It arrived well packaged and intact. For the results it delivers, I consider it an amazing value and will absolutely repurchase again and again.
If you’re on the fence about trying this, go for it — it truly rescued and revived my skin barrier. This is now a permanent part of my routine and 100% a holy grail product for me!
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Reviewed in the United States on October 23, 2025
★★★★★ 5
Hydrating and Powerful Barrier Repair Serum!💧
This serum has been life-changing in calming and restoring my skin barrier. It absorbs quickly, feels lightweight, and instantly soothes irritation without feeling greasy. I’ve noticed my skin looks healthier and more balanced after just a few uses. It’s gentle enough for sensitive skin and works especially well when my skin barrier feels compromised. It is also fragrance-free, which I always appreciate! Trust me, it’s well worth the money!
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Reviewed in the United States on December 28, 2025
★★★★★ 5
Works as created.
Have been using for a few weeks and have noticed 15% improvement in skin and issues. I did notice a difference in the first 24 hours as advertised. It is suggested need a full month I think to see the true results.
At 50 I have pre menopausal skin issues- the redness & inflammation, acne, tightness and sensitivity. It is helping in addition to the other Avene skin products that come in the trial box for sensitive or SOS skin box trial size I think ot is called.
This has made a difference. It is easy to apply. I use morning and night. It is different from the Cicalfate + Cream. I use that also as needed. I am happy and recommend it. The price is higher than what I spend. But I wanted to try it to see of i need more than just what was in the Avene sensitive skin trial size box they have. My skin is really red and irritated so the $40 for the bottle is was willing to try because it's painful on my face.
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Reviewed in the United States on April 23, 2026
★★★★★ 4
Okay serum, not as good as the cream though
I am obsessed with the cream version of this so I thought I’d give this a try. The dropper top allows for easy application. The formula is light and non greasy and absorbs easily. No harsh fragrances. I would use it when I had eczema flares on my face and feel like it didn’t work near as well in helping with skin irritation as the cream does. As of now I don’t use it as part of my regular skin care. Do I think it’s a bad product? No, but it didn’t really work wonders for me. Not sure I would purchase again.
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Reviewed in the United States on May 21, 2026
★★★★★ 5
Helps with redness and softens skin
I have sensitive, mild rosacea skin. Had a facial recently and the aesthetician suggested I get a serum to help with moisturizer as I am almost 40. I’ve tried a lot of serums and either they are sticky and not really hydrating or break my skin out in a rash. This serum is amazing. Helps calm the redness in my cheeks and my skin is moisturized and soft all day. It feels a little sticky at first but it goes away. I apply in this order OSEA sea mineral mist toner to prep the skin, this serum and top off with Chanel La Solution 10 for sensitive skin.
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Reviewed in the United States on December 27, 2025
